Senate Majority Leader Harry Reid of Nevada said in a statement: ''I have the greatest respect for Joe, but I simply have to disagree with his decision to endorse Senator McCain.''
Al From, the founder and CEO of the centrist Democratic Leadership Council, said, ''I am very saddened by Senator Lieberman's choice and profoundly disagree with it. We need to elect a Democratic president in 2008.''
For McCain, behind in the polls here but gaining, the endorsement carries the risk of alienating conservatives who have been critical of his support for immigration and campaign finance reforms.
''If I get some criticism for aligning myself with a good friend I have worked with for many years, I will be more than happy to accept that criticism,'' McCain said.
For Lieberman, it marks another turn away from the Democrats.
''Political party is important, but it's not more important than what's good for the country and it's not more important than friendship,'' Lieberman said.
Lieberman won re-election to the Senate in 2006 as an independent, after losing the Democratic primary to upstart Ned Lamont largely because of his support for the war. High-profile Democrats abandoned him after the primary defeat, including his Connecticut colleague, Sen. Chris Dodd.
Although Dodd also is seeking the presidency, Lieberman backed McCain. He said he had intended to wait until after the primaries to make a choice for the 2008 presidential race, but McCain asked for his support and no Democrat did.